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Frequently Asked Questions

AFINITOR Tablets and AFINITOR DISPERZ 

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Q: How will I know if AFINITOR® (everolimus) is shrinking my SEGA tumors?

A: The only way to know if your SEGA tumors are shrinking is to get regular scans of your brain per your doctor's treatment plan. Learn the results of studies of AFINITOR in patients with TSC-related brain tumors (SEGAs).


Q: How many people with TSC-related SEGA have been treated with AFINITOR?

A: AFINITOR has been prescribed to more than 1200 patients with TSC-related SEGA since 2010.

Q: How many medications are available to treat TSC-related brain tumors?
A: AFINITOR is the only FDA-approved medication to treat people with TSC who have brain tumors called SEGA. AFINITOR can be prescribed for SEGAs that cannot be removed completely by surgery (for use in adults and children).

Q: Why are there 2 different ways to take AFINITOR, as tablets and as DISPERZ?
A: AFINITOR DISPERZ is a tablet that dissolves in water. It is available as an option for patients who are not able to swallow pills.

Q: How should I take AFINITOR or AFINITOR DISPERZ? 
A: Your health care provider will prescribe the dose of AFINITOR or AFINITOR DISPERZ that is right for you.
Take AFINITOR or AFINITOR DISPERZ exactly as your health care provider tells you to. See How to Take Treatment for more information.

  • Take AFINITOR or AFINITOR DISPERZ one time each day at about the same time
  • Take AFINITOR or AFINITOR DISPERZ the same way each time, either with food or without food
  • If you take too much AFINITOR or AFINITOR DISPERZ, contact your health care provider or go to the nearest hospital emergency department right away. Take the pack of AFINITOR or AFINITOR DISPERZ with you
  • If you miss a dose of AFINITOR or AFINITOR DISPERZ, you may still take it up to 6 hours after the time you normally take it. If it is more than 6 hours after you normally take your AFINITOR or AFINITOR DISPERZ, skip the dose for that day. The next day, take AFINITOR or AFINITOR DISPERZ at your usual time. Do not take 2 doses to make up for a missed dose. If you are not sure about what to do, call your health care provider

 

AFINITOR tablets:

  • Swallow AFINITOR tablets whole with a glass of water. Do not take any tablet that is broken or crushed

 

AFINITOR DISPERZ:

  • If your health care provider prescribes AFINITOR DISPERZ for you, see the “Instructions for Use” that come with your medicine for instructions on how to prepare and take your dose. You can also watch a video on how to prepare AFINITOR DISPERZ 
  • Each dose of AFINITOR DISPERZ must be prepared as a suspension before it is given
  • AFINITOR DISPERZ can cause harm to an unborn baby. When possible, the suspension should be prepared by an adult who is not pregnant or planning to become pregnant
  • Wear gloves to avoid possible contact with everolimus when preparing suspensions of AFINITOR DISPERZ for another person

 

Q: What are other important things I should know while taking AFINITOR?

A: You should not drink grapefruit juice or eat grapefruit during your treatment with AFINITOR or AFINITOR DISPERZ. It may make the amount of AFINITOR in your blood increase to a harmful level. Avoid the use of live vaccinations and contact with individuals who have received live vaccinations. If you are not sure about the type of vaccine, ask your health care professional. Click here for additional information on what to avoid.

Q: How does AFINITOR work?

A: Tuberous sclerosis cells typically have changes in their TSC1 or TSC2 genes that make them different from normal cells. These gene changes might cause the cell to make too much of a protein called mammalian target of rapamycin (mTOR). This, in turn, might make the cell grow and divide too quickly, causing a tumor to form. AFINITOR targets mTOR, blocking its effects and thereby reducing the growth of tumor cells. The blocking of mTOR by AFINITOR has been shown to slow the increase in the number of tumor cells and decrease the creation of new blood vessels within the tumor. This was based on data obtained in a laboratory environment as well as studies in living cells.