Side Effect Management

AFINITOR® (everolimus) Tablets

Management of Mouth Sores When Starting AFINITOR

Mouth sores are the most common side effect of AFINITOR® (everolimus) Tablets. They can appear as early as within 2 weeks of treatment or at any time during treatment. When starting AFINITOR, your doctor may prescribe alcohol-free dexamethasone-based oral solution to reduce the likelihood of mouth sores occurring, or reduce the severity if they do occur.


If you develop pain, discomfort, or open sores in your mouth, tell your health care provider. Your health care provider may tell you to re-start this mouthwash or to use a special mouthwash or mouth gel that does not contain alcohol, hydrogen peroxide, iodine, or thyme.

FREE 8-Week Supply of Alcohol-Free Dexamethasone-Based Oral Solution

Terms and Conditions

The voucher is good for one 8-week supply of dexamethasone solution, 0.5 mg/5 mL (1 bottle = 240 mL), or dexamethasone solution, 0.5 mg/5 mL (1 bottle = 500 mL). This free trial is not health insurance. Void where prohibited by law. No purchase required. Prescriber ID# required on prescription. It is illegal for any person to sell, purchase, or trade; or offer to sell, purchase, or trade; or to counterfeit this voucher. Claim shall not be submitted to any public or private third-party payer of any federal or state health care program for reimbursement. Valid only in the United States and Puerto Rico. Offer not valid if reproduced or submitted to any other payer. 


Always follow your doctor’s instructions, and contact your doctor or nurse if you are having any problems.

Dexamethasone Doctor Discussion Guide

Use these topics to help guide a discussion about dexamethasone oral solution with your doctor.

  • Confirm the amount of dexamethasone oral solution your doctor has prescribed.
  • Record the length of time your doctor has told you to swish the solution in your mouth.
  • Ask your doctor about any food or drink restrictions that are related to your dexamethasone oral solution.
  • Note how many times your doctor wants you to use the solution each day.


Some Other Oral Care Tips Your Doctor Might Recommend

Things to Do

  • Eat soft foods (such as milkshakes, smoothies, pudding, yogurt, mashed potatoes, or bananas)
  • Take good care of your mouth and visit your dentist regularly
  • Try to brush after every meal with a soft-bristled toothbrush and mild toothpaste
  • Rinse your mouth several times a day with a saltwater mixture
  • If you’re flossing with dental floss, continue with your daily flossing routine. If you have not been flossing daily, do not start, because your mouth may become more sensitive
  • Check with a doctor, nurse, or pharmacist before using a store-bought mouthwash


Things to Avoid

  • Foods and drinks that can irritate your mouth (such as citrus fruits and juices, tomatoes, spicy or salty foods, raw ginger, onions, and crunchy chips)
  • Mouthwash that contains alcohol, hydrogen peroxide, iodine, or thyme because it may irritate your mouth
  • Drinking hot liquids or beverages
  • Eating foods that you are allergic to
  • Also, keep in mind any dietary restrictions you may have


Discuss Any Side Effects You’re Having

  • It is important that you report any side effects you’re having as soon as possible to your doctor or nurse
  • Your doctor may change your dose of AFINITOR or tell you to temporarily stop treatment if needed
  • Flexible dosing can be a normal part of treatment, and it helps your doctor find the dose of AFINITOR that’s right for you
  • You should not change or adjust your dose by yourself
  • Always follow your doctor’s instructions, and call your doctor or nurse if you are having any problems