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Frequently Asked Questions

AFINITOR

In this section you will find answers to questions commonly asked by patients who have been prescribed AFINITOR® (everolimus) Tablets.

Questions About Neuroendocrine Tumors

Progression means that the tumor has become worse or spread from where it started in the lung. Lung neuroendocrine tumors (NET) tend to be slow growing and patients may have no noticeable symptoms. By the time most patients are diagnosed, their lung NET has progressed.

Lung NET is a rare form of cancer that starts in the lung. Other common terms for progressive lung NET are pulmonary NET and lung carcinoid tumors.

Questions About AFINITOR

Take AFINITOR® (everolimus) Tablets once a day at the same time each day. AFINITOR is a prescription medicine that is a once-daily oral tablet. Your doctor will prescribe the dose of AFINITOR that is right for you. Take AFINITOR exactly as prescribed by your doctor. When you start treatment with AFINITOR, your health care provider may also prescribe a mouthwash to reduce the likelihood of getting mouth ulcers or sores and to reduce their severity. Follow your health care provider’s instructions on how to use this prescription mouthwash. Your doctor may change your dose or tell you to temporarily interrupt dosing, if needed.

Use scissors to open the blister pack. Swallow AFINITOR tablets whole with a glass of water. Do not take any tablet that is broken or crushed. Either always take AFINITOR with food or always take AFINITOR without food.

You should have blood tests before you start AFINITOR and as needed during your treatment.

These will include tests to check your blood cell count, kidney and liver function, cholesterol, and blood sugar levels.

You should not drink grapefruit juice or eat grapefruit during your treatment with AFINITOR. It may make the amount of AFINITOR in your blood increase to a harmful level. 

Do not take AFINITOR if you are allergic to everolimus or to any of the ingredients in AFINITOR. See below for a complete list of ingredients in AFINITOR. Talk to your health care provider before taking this medicine if you are allergic to: sirolimus (Rapamune®), temsirolimus (Torisel®). Ask your health care provider if you do not know.

Active ingredient: everolimus.

Inactive ingredients: anhydrous lactose, butylated hydroxytoluene, crospovidone, hypromellose, lactose monohydrate, and magnesium stearate.

If you take too much AFINITOR contact your health care provider or go to the nearest hospital emergency room right away. Take the pack of AFINITOR with you.

If you miss a dose of AFINITOR, you may still take it up to 6 hours after the time you normally take it. If it is more than 6 hours after you normally take your AFINITOR, skip the dose for that day. The next day, take AFINITOR at your usual time. Do not take 2 doses to make up for a missed dose. If you are not sure about what to do, call your health care provider.

  • Store AFINITOR at room temperature, between 68°F to 77°F (20°C to 25°C).
  • Keep AFINITOR in the pack it comes in.
  • Open the blister pack just before taking AFINITOR.
  • Keep AFINITOR dry and away from light.
  • Do not use AFINITOR that is out of date or no longer needed.

Keep AFINITOR and all medicines out of the reach of children.

Before taking AFINITOR, tell your health care provider about all of your medical conditions, including if you:

  • Have or have had kidney problems
  • Have or have had liver problems
  • Have diabetes or high blood sugar
  • Have high blood cholesterol levels
  • Have any infections
  • Previously had hepatitis B
  • Are scheduled to receive any vaccinations. You should not receive a "live vaccine" or be around people who have recently received a "live vaccine" during your treatment with AFINITOR. If you are not sure about the type of immunization or vaccine, ask your health care provider.
  • Are pregnant, could become pregnant, or have a partner who could become pregnant. AFINITOR can cause harm to your unborn baby. If you are a woman who is able to become pregnant you should use effective birth control during treatment and for 8 weeks after your last dose of AFINITOR. If you are a man with a woman partner, you should use effective birth control during treatment and for 4 weeks after your last dose of AFINITOR. Talk to your health care provider about birth control methods that may be right for you during this time. If you become pregnant or think you are pregnant, tell your health care provider right away.
  • Are breastfeeding or plan to breastfeed. It is not known if AFINITOR passes into your breast milk. Do not breastfeed during treatment and for 2 weeks after your last dose of AFINITOR.
  • Are about to have surgery, if you have had a recent surgery, or if you have an unhealed wound

Tell your health care provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

AFINITOR may affect the way other medicines work, and other medicines can affect how AFINITOR works. Taking AFINITOR with other medicines can cause serious side effects.

Know the medicines you take. Keep a list of them and show it to your health care provider and pharmacist when you get a new medicine. Especially tell your health care provider if you take:

  • St. John's Wort (Hypericum perforatum)
  • Medicine for:
    • Fungal infections
    • Bacterial infections
    • Tuberculosis
    • Seizures
    • HIV-AIDS
    • Heart conditions or high blood pressure
  • Medicines that weaken your immune system (your body's ability to fight infections and other problems)

Ask your health care provider or pharmacist if you are not sure if your medicine is one of those taken for the conditions listed above. If you are taking any medicines for the conditions listed above, your health care provider might need to prescribe a different medicine or your dose of AFINITOR may need to be changed. You should also tell your health care provider before you start taking any new medicine.