Frequently Asked Questions*

AFINITOR® (everolimus) Tablets

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Q: How will I know if AFINITOR® (everolimus) Tablets is working on my kidney tumors? 

A: The only way to know if your kidney tumors are shrinking is to get regular scans of your kidneys per your doctor's treatment planLearn the results of a study of AFINITOR in patients with TSC-associated kidney tumors (renal angiomyolipomas).


Q: How many medications are available to treat TSC-associated kidney tumors? 

A: AFINITOR is the only FDA-approved medication to treat adults with TSC who have kidney tumors called renal angiomyolipomasAFINITOR can be prescribed for TSC-associated renal angiomyolipomas that cannot be removed completely by surgery. 

Q: How should I take AFINITOR® (everolimus) Tablets?  

A: Your health care provider will prescribe the dose of AFINITOR that is right for you. Take AFINITOR exactly as your health care provider tells you to. See How to Take Treatment for more information.

  • Take AFINITOR one time each day at about the same time 
  • Take AFINITOR the same way each time, either with food or without food 
  • Swallow AFINITOR whole with a glass of water. Do not take any tablet that is broken or crushed
  • If you take too much AFINITOR, contact your health care provider or go to the nearest hospital emergency room right away. Take the pack of AFINITOR with you 
  • If you miss a dose of AFINITOR, you may still take it up to 6 hours after the time you normally take it. If it is more than 6 hours after you normally take your AFINITOR, skip the dose for that day. The next day, take AFINITOR at your usual time. Do not take 2 doses to make up for a missed dose. If you are not sure about what to do, call your health care provider 


Q: What are other important things I should know while taking AFINITOR? 

A: You should not drink grapefruit juice or eat grapefruit during your treatment with AFINITOR. It may make the amount of AFINITOR in your blood increase to a harmful level. Avoid the use of live vaccinations and contact with individuals who have received live vaccinations. If you are not sure about the type of vaccine, ask your health care professional. Click here for additional information on what to avoid. 

Q: How does AFINITOR® (everolimus) Tablets work? 

A: Tuberous sclerosis cells typically have changes in their TSC1 or TSC2 genes that make them different from normal cells. These gene changes might cause the cell to make too much of a protein called mammalian target of rapamycin (mTOR). This, in turn, might make the cell grow and divide too quickly, causing a tumor to form. AFINITOR targets mTOR, blocking its effects and thereby reducing the growth of tumor cells. The blocking of mTOR by AFINITOR has been shown to slow the increase in the number of tumor cells and decrease the creation of new blood vessels within the tumor. This was based on data obtained in a laboratory environment as well as studies within living cells.


Q: What illnesses does AFINITOR treat? 

A: AFINITOR has been used for years to effectively treat different types of diseases. It has been used in the United States since 2012 to treat TSC-associated renal angiomyolipoma. 


Q: Is AFINITOR a cancer drug? 

A: AFINITOR treats several forms of cancer, but it is also effective in noncancerous disease, such as TSC-associated renal angiomyolipoma. It is not chemotherapy or radiation. 

*Your health care professional is the best source of information regarding your conditions and therapy.