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Understanding Treatment

Treatment With AFINITOR

What is AFINITOR?

AFINITOR® (everolimus) Tablets is a prescription medicine used to treat adults with advanced kidney cancer (renal cell carcinoma or RCC) when certain other medicines (ie, sunitinib or sorafenib) have not worked. AFINITOR may slow the growth and spread of kidney cancer cells and reduce blood supply to the tumor.

 

If you have previously taken sunitinib or sorafenib and had to stop because your cancer progressed, AFINITOR might be right for you. AFINITOR is a tablet you take once daily, consistently with or consistently without food.

 

You may take AFINITOR at home or any other place that works for you. This may eliminate the need to receive treatment in your doctor's office. AFINITOR should be taken at the same time every day.

Important Safety Information

Patients should not take AFINITOR if they are allergic to AFINITOR or to any of its ingredients. Patients should tell their health care provider before taking AFINITOR if they are allergic to sirolimus or temsirolimus.

Treatment with AFINITOR

  • AFINITOR is a prescription medicine used to treat adults with advanced kidney cancer (renal cell carcinoma or RCC) when certain other medicines (ie, sunitinib or sorafenib) have not worked.
  • AFINITOR is a type of medicine called an mTOR (mammalian target of rapamycin) inhibitor. It is the only mTOR inhibitor approved for the treatment of advanced kidney cancer that is available as a once-daily tablet. It directly affects the cancer in two places–in the cancer cell and in the blood vessels that help feed the cancer cells.* This means that AFINITOR may help make it harder for the cancer to grow and spread to other parts of your body. AFINITOR also affects healthy, nontumor cells.
* Blocking the mTOR pathway with AFINITOR has been shown to slow the growth and spread of advanced kidney cancer, reduce cancer growth, and slow blood vessels from growing and feeding tumors in laboratory studies, as well as in living humans and animals. 

How AFINITOR works

The way a medicine works inside your body is called the mechanism of action (MOA). The MOA of AFINITOR is different than other medicines.

 

AFINITOR works by fighting advanced kidney cancer in two places*:

  1. In the cancer cell
  2. In the blood vessels that help feed the cancer cells