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Before Starting Treatment

AFINITOR

Before taking AFINITOR

Before you start treatment with AFINITOR® (everolimus) Tablets, it is important to tell your health care provider about all prescription and nonprescription medicines, vitamins, and herbal supplements you take. This is important because some of these may affect how AFINITOR works, or AFINITOR may affect how they work. Using AFINITOR with other medicines can cause serious side effects.

 

Make sure to tell your health care provider if you take:

  • St. John's wort (Hypericum perforatum)
  • Medicine for:
    • Fungal or bacterial infections
    • Tuberculosis
    • Seizures
    • HIV-AIDS
    • Heart conditions or high blood pressure
  • Medicines that suppress your immune system (your body's ability to fight infections and other problems)

 

Ask your health care provider or pharmacist if you are not sure if you take medicine for one of the conditions listed above. If you are, your health care provider might need to prescribe a different medicine or your dose of AFINITOR may need to be changed. Always talk with your health care provider before you start taking any new medicine.

Other things to tell your health care provider before taking AFINITOR

Talk to your health care provider before taking AFINITOR if you are allergic to any of the following:

  • Sirolimus
  • Temsirolimus

 

Besides telling your health care provider about all the medicines you are taking, you should also tell him/her about any medical conditions you have, including if you:

  • Have or have had kidney problems
  • Have or have had liver problems
  • Have diabetes or high blood sugar
  • Have high blood cholesterol levels
  • Have any infections
  • Previously had hepatitis B
  • Are scheduled to receive any vaccinations. You should not receive a live vaccine or be around people who have recently received a live vaccine during your treatment with AFINITOR. If you are not sure about the type of vaccine, ask your health care provider
  • Have other medical conditions
  • Are pregnant or could become pregnant, or have a partner who could become pregnant. AFINITOR can cause harm to your unborn baby. If you are a woman who is able to become pregnant, you should use effective birth control while using AFINITOR and for 8 weeks after your last dose. If you are a male with a woman partner, you should use effective birth control during treatment and for 4 weeks after your last dose. Talk to your health care provider about birth control options while taking AFINITOR
  • Are breastfeeding or plan to breastfeed. Do not breastfeed during treatment and for 2 weeks after your last dose
  • Are about to have surgery, if you have had a recent surgery, or if you have an unhealed wound

Possible drug interactions with AFINITOR® (everolimus) Tablets

Some kinds of medicines may lower or raise the amount of AFINITOR in your blood. Your health care provider may need to change the dose of these medicines, the dose of AFINITOR, or prescribe a totally different medicine. Be sure to tell your health care provider about all of the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements.

 

The following medicines may lower or raise the amount of AFINITOR in your blood. This list does not include all the medicines that may affect the amount of AFINITOR in your blood. Check with your health care provider for additional medications that might affect AFINITOR.

 

Medicines for seizures:

  • Carbamazepine
  • Phenobarbital
  • Phenytoin

 

Medicines for tuberculosis:

  • Rifabutin
  • Rifampin
  • Rifapentine

 

Medicines for infections:

  • Clarithromycin
  • Erythromycin
  • Telithromycin

 

Medicines for nausea and vomiting:

  • Aprepitant

 

Medicines for fungal infections:

  • Fluconazole
  • Itraconazole
  • Ketoconazole
  • Voriconazole
  • Nefazodone

 

Medicines for HIV-AIDS:

  • Amprenavir
  • Atazanavir
  • Fosamprenavir
  • Ritonavir
  • Saquinavir

 

Medicines for heart conditions and high blood pressure:

  • Diltiazem
  • Verapamil

 

The names of the medicines in this list are generic and may be different from the branded names of your medicines. Ask your health care provider or pharmacist if you are not sure if any of your medicines is one of those listed above.