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Understanding Treatment



AFINITOR® (everolimus) Tablets is a prescription medicine used to treat adults with a type of pancreatic cancer known as pancreatic neuroendocrine tumor (PNET) that has progressed and cannot be treated with surgery.

AFINITOR is not for use in people with carcinoid tumors that actively produce hormones.

Understanding How AFINITOR Works

AFINITOR works by blocking the mammalian target of rapamycin (mTOR) protein*. In doing so, AFINITOR helps to slow blood vessels from feeding oxygen and nutrients to the tumor. AFINITOR may also affect healthy, nontumor cells.

AFINITOR® (everolimus) blocking the mammalian target of rapamycin (mTOR) protein

*Although AFINITOR has been studied in patients with advanced PNET, how AFINITOR works has been demonstrated only in laboratory studies.

Keep Your Doctor Informed

Having the freedom to take your medicine at home gives you the responsibility for taking it correctly every day. It is important to tell your doctor as soon as possible about any side effects you have while taking AFINITOR. If you report side effects as soon as they start, your health care provider can suggest ways to help manage your therapy. Don’t delay reporting symptoms, as they may worsen. Your doctor may have to reduce the dose of AFINITOR or stop AFINITOR until symptoms get better.

Share lists of all your prescription medicines, over-the-counter medicines, and herbal supplements and vitamins with your health care provider and your pharmacist. Talk with your health care provider before starting any new medicine.

Getting to Know Your Health Care Team

Making sure you have a knowledgeable health care team is important. Take the time to do some background research on the doctors, nurses, and other health care professionals who will be part of your team.

Your health care team can provide you with information about your PNET prognosis, treatment options, and patient-support programs. As your treatment journey continues, be sure to listen and communicate with your health care team in an honest and open way.

These are some of the people your health care team may include:

  • Oncologist: Oncologists are doctors specially trained to treat people who have cancer. They are experts in the field of cancer and cancer therapies. In many cases, your health care team will be led by your oncologist. He or she will work with you to develop a plan of action and will remain with you throughout your journey.
  • Surgical Oncologist: This doctor has a medical degree in surgery, with further training in the removal and treatment of cancerous tumors.
  • Oncology Nurse: Your oncology nurse works closely with your oncologist to implement your treatment plan and support your needs throughout treatment. Oncology nurses have gone through special training and certification to help treat people who have cancer. A lot of your day-to-day contact with your oncologist's office will be through your oncology nurse. Your oncology nurse may be able to answer many of your questions and help manage any side effects you may experience. It's likely that you will form a relationship with your oncology nurse as you travel along your treatment journey.
  • Oncology Clinic Staff: As they become the familiar and supportive faces that you encounter at most visits, your oncology clinic staff can be a valuable resource for information about advanced PNET and your treatment. They can also refer you to online support organizations.
  • Oncology Social Worker: An oncology social worker can help counsel patients and their families on coordinating cancer care, learning coping skills, and adjusting to changes in lifestyle. They may also help connect people with cancer support groups in the community and aid with any financial concerns.
  • Case Manager: A case manager (or care manager) is a person with training and experience in helping coordinate the care of people with cancer. Case managers are usually assigned to you through your health plan and can assist with any insurance issues and help determine your coverage.

Once Diagnosed With PNET, What Can You Do?