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How Treatment May Help
Treatment With AFINITOR
- AFINITOR® (everolimus) Tablets may slow the growth and spread of advanced pancreatic neuroendocrine tumors (PNET). The benefits and risks of AFINITOR have been examined in a large clinical trial studying advanced PNET that has progressed and cannot be treated with surgery, including more than 400 patients with these tumors.
- For patients taking AFINITOR, tumor growth was delayed for twice as long compared with patients taking a placebo sugar pill (11.0 months for AFINITOR patients compared with 4.6 months for patients on placebo). Approximately 4.8% of patients taking AFINITOR experienced a reduction in tumor size. No patients became tumor-free. It’s important to note that an increase in overall survival has not been shown.
Before Starting Treatment With AFINITOR
Before you start treatment with AFINITOR, it is important to tell your doctor about all prescription and over-the-counter medicines, vitamins, and herbal supplements you are taking. This is important because some of these may affect how AFINITOR works, or AFINITOR may affect how they work. Using AFINITOR with other medicines can cause serious side effects.
Keep a list of medicines you take and show it to your health care provider when you get a new medicine.
Especially tell your doctor if you take St John’s wort (Hypericum perforatum), medicines that weaken your immune system (your body’s ability to fight infections and other problems), or medicines for:
- Fungal infections
- Bacterial infections
- Heart conditions or high blood pressure
Ask your health care provider or pharmacist if you are not sure if your medicine is one of those taken for the conditions listed above. If you are taking any medicines for the conditions listed above, your health care provider might need to prescribe a different medicine or your dose of AFINITOR may need to be changed. You should also tell your health care provider before you start taking any new medicine.
Other Things to Tell Your Doctor Before Taking AFINITOR
Talk to your health care provider before taking this medicine if you are allergic to:
- sirolimus (Rapamune®)
- temsirolimus (Torisel®)
Ask your health care provider if you do not know.
Before taking AFINITOR, tell your health care provider about all of your medical conditions, including if you:
- Have or have had kidney problems
- Have or have had liver problems
- Have diabetes or high blood sugar
- Have high blood cholesterol levels
- Have any infections
- Previously had hepatitis B
- Are scheduled to receive any vaccinations. You should not receive a live vaccine or be around people who have recently received a live vaccine during your treatment with AFINITOR. If you are not sure about the type of vaccine, ask your health care provider
- Are pregnant, could become pregnant, or have a partner who could become pregnant. AFINITOR can cause harm to your unborn baby. If you are a woman who is able to become pregnant, you should use effective birth control while using AFINITOR and for 8 weeks after your last dose of AFINITOR. If you are a man with a woman partner, you should use effective birth control during treatment and for 4 weeks after your last dose of AFINITOR. Talk to your health care provider about birth control options while taking AFINITOR. If you become pregnant or think you are pregnant, tell your health care provider right away
- Are breastfeeding or plan to breastfeed. It is not known if AFINITOR passes into your breast milk. Do not breastfeed during treatment and for 2 weeks after your last dose of AFINITOR
- Are about to have surgery, if you have had a recent surgery, or if you have an unhealed wound
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