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AFINITOR® (everolimus) Tablets can cause side effects in some individuals, and every patient's experience with AFINITOR will be different. Some people will experience more serious side effects than other people. Remember to talk to your doctor about any side effects that may appear so that together you can work to find a way to try to manage them.
You may develop lung or breathing problems. In some patients, lung or breathing problems may be severe and can even lead to death.
Consult with your health care provider before stopping, interrupting, or lowering your dose of AFINITOR. Tell your health care provider right away if you have any of these symptoms:
You may be more likely to develop an infection, such as pneumonia, or a bacterial, fungal, or viral infection. Viral infections may include reactivation of hepatitis B in patients who have had hepatitis B in the past. In some patients, these infections may be severe and can even lead to death. You may need to be treated as soon as possible.
Tell your health care provider right away if you have a temperature of 100.5°F or above, chills, or do not feel well. Symptoms of hepatitis B or infection may include:
You may develop a severe allergic reaction. Severe allergic reactions can happen in people who take AFINITOR. Call your health care provider or get medical help right away if you get signs and symptoms of a severe allergic reaction, including rash, itching, hives, flushing, trouble breathing or swallowing, chest pain, or dizziness.
You may develop angioedema. Patients who take an angiotensin-converting enzyme (ACE) inhibitor medicine during treatment with AFINITOR are at a possible increased risk for a type of allergic reaction called angioedema. Talk with your health care provider before taking AFINITOR if you are not sure if you take an ACE inhibitor medicine. Get medical help right away if you have trouble breathing or develop swelling of your tongue, mouth, or throat during treatment with AFINITOR.
You may develop kidney failure. In some people, this may be severe and can even lead to death. Your doctor should do tests to check your kidney function before and during your treatment with AFINITOR.
You may have delayed wound healing. AFINITOR can cause incisions to heal slowly or not heal well. Call your health care provider right away if your incision is red, warm, or painful; if you have blood, fluid, or pus in your incision; if your incision opens up; or if your incision swells.
You may have increased blood sugar and fat (cholesterol and triglycerides) levels in blood. Your health care provider should do blood tests to check your fasting blood sugar, cholesterol, and triglyceride levels in the blood before you start and during treatment with AFINITOR.
You may have decreased blood cell counts. AFINITOR can cause you to have decreased red blood cells, white blood cells, and platelets. Your health care provider should do blood tests to check your blood cell counts before you start and during treatment with AFINITOR.
Before taking AFINITOR, tell your health care provider about all your medical conditions, including if you:
Have or have had kidney problems
Have or have had liver problems
Have diabetes or high blood sugar
Have high blood cholesterol levels
Have any infections
Previously had hepatitis B
Are scheduled to receive any vaccinations. You should not receive a live vaccine or be around people who have recently received a live vaccine during your treatment with AFINITOR. If you are not sure about the type of vaccine, ask your health care provider
Are pregnant or could become pregnant, or have a partner who could become pregnant. AFINITOR can cause harm to your unborn baby. If you are a woman who is able to become pregnant, you should use effective birth control while using AFINITOR and for 8 weeks after your last dose. If you are a male with a woman partner, you should use effective birth control during treatment and for 4 weeks after your last dose. Talk to your health care provider about birth control options while taking AFINITOR
Are breastfeeding or plan to breastfeed. Do not breastfeed during treatment and for 2 weeks after your last dose
Are about to have surgery, if you have had a recent surgery, or if you have an unhealed wound
Tell your health care provider about all of the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements. Using AFINITOR with certain other medicines can cause serious side effects. Keep a list of medicines you take, and show it to your health care provider when you get a new medicine. Especially tell your health care provider if you take St John’s wort (Hypericum perforatum), medicines that weaken your immune system (your body’s ability to fight infections and other problems), or medicines for:
If you are taking any medicines for the conditions listed above, your health care provider might need to prescribe a different medicine or your dose of AFINITOR may need to be changed. Tell your health care provider before you start taking any new medicine.
If you have any of the serious side effects listed above, you may need to stop taking AFINITOR for a while or use a lower dose. Follow your health care provider's instructions.
Some of the most common side effects of AFINITOR in people with advanced kidney cancer include:
Other side effects that may occur with AFINITOR:
Tell your health care provider if you have any side effect that bothers you or does not go away.
These are not all the possible side effects of AFINITOR. For more information, ask your health care provider or pharmacist or call 1-888-669-6682.