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Before Starting Treatment


Before taking AFINITOR

Before you start treatment with AFINITOR® (everolimus) Tablets, it is important to tell your doctor about all prescription and nonprescription medicines, vitamins, and herbal supplements you are taking. This is important because some of these may affect how AFINITOR works, or AFINITOR may affect how they work. Using AFINITOR with other medicines can cause serious side effects.


Especially tell your health care provider if you take:

  • St. John's wort (Hypericum perforatum)
  • Medicine for:
    • Fungal or bacterial infections
    • Tuberculosis
    • Seizures
    • HIV/AIDS
    • Heart conditions or high blood pressure
  • Medicines that suppress your immune system (your body's ability to fight infections and other problems)


Ask your health care provider or pharmacist if you are not sure if your medicine is among those taken for the conditions listed above. If you are taking any medicines for the conditions listed above, your health care provider might need to prescribe a different medicine or your dose of AFINITOR may need to be changed. You should also tell your health care provider before you start taking any new medicine.

Other things to tell your doctor before taking AFINITOR

Talk to your doctor before taking AFINITOR if you are allergic to any of the following:

  • Sirolimus (Rapamune®)
  • Temsirolimus (Torisel®)


Besides telling your doctor about all the medicines you are taking, you should also tell him/her about any medical conditions you have, including if you:

  • Have or have had kidney problems
  • Have or have had liver problems
  • Have diabetes or high blood sugar
  • Have high blood cholesterol levels
  • Have any infections
  • Previously had hepatitis B
  • Are scheduled to receive any vaccinations. You should not receive a live vaccine or be around people who have recently received a live vaccine during your treatment with AFINITOR. If you are not sure about the type of vaccine, ask your health care provider
  • Are pregnant or could become pregnant. AFINITOR can cause harm to your unborn baby. If you are able to become pregnant, you should use effective birth control while using AFINITOR and for 8 weeks after your last dose. Talk to your health care provider about birth control options while taking AFINITOR
  • Are breastfeeding or plan to breastfeed. Do not breastfeed during treatment and for 2 weeks after your last dose

Possible drug interactions with AFINITOR® (everolimus) Tablets

Some kinds of medicines may lower or raise the amount of AFINITOR in your blood. Your doctor may need to change the dose of these medicines, the dose of AFINITOR, or prescribe a totally different medicine. Be sure to tell your doctor if you are taking any other medicines including (prescription or nonprescription) medicines, vitamins, or herbal supplements.


The following medicines may lower or raise the amount of AFINITOR in your blood. This list does not include all the medicines that may affect the amount of AFINITOR in your blood. Check with your doctor for additional medications that might interact with AFINITOR.


Medicines for seizures:

  • Carbamazepine
  • Phenobarbital
  • Phenytoin


Medicines for tuberculosis:

  • Rifabutin
  • Rifampin
  • Rifapentine


Medicines for infections:

  • Clarithromycin
  • Erythromycin
  • Telithromycin


Medicines for nausea and vomiting:

  • Aprepitant


Medicines for fungal infections:

  • Fluconazole
  • Itraconazole
  • Ketoconazole
  • Voriconazole
  • Nefazodone


Medicines for HIV/AIDS:

  • Amprenavir
  • Atazanavir
  • Fosamprenavir
  • Ritonavir
  • Saquinavir


Medicines for heart conditions and high blood pressure:

  • Diltiazem
  • Verapamil


The names of the medicines in this list are generic and may be different from the branded names of your medicines. Ask your health care provider or pharmacist if you are not sure if any of your medicines is one of those listed above.